Sara Metwally Abdallah Mohamed Abdelsayed
Lecturer
Citrate-capped AuNPs-induced redox reprogramming modulates the TP53–BAX/BCL2–CASP3 Axis, reinforcing antioxidant defense and promoting apoptotic signaling in liver Cancer
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy • 2026
Publication Information
Authors
A Elmetwalli; Sara Abdelsayed; M G Hassan; Ibtisam Aboud Almutairi; Deema Kamal Sabir; Hassnaa Elsherbiny; Ashraf Elsayed
Keywords
Gold nanoparticles; Hepatocellular carcinoma; TP53; Apoptosis; Redox reprogramming
Journal
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Publisher
Elsevier
Volume
344
Issue
Part 1
Pages
126630
publication.type
International
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
Gold nanoparticles (AuNPs) capped with citrate were assessed for selective cytotoxicity in HepG2 liver cancer cells compared to normal fibroblasts. AuNPs induced redox reprogramming, affecting TP53, BAX, BCL2, and CASP3 expression, disrupted mitochondrial membrane potential, and enhanced antioxidant defense, leading to apoptosis. These findings suggest potential nanomedicine strategies targeting cancer cell vulnerabilities