Background: Inadequate knowledge about menopause among women leading to impaired quality of life (QOL). Paying attention to health promotion through lifestyle modification is an important measure to improve the health and quality of life of menopausal women. Aim: to evaluate the effect of health promoting lifestyle educational intervention on knowledge and quality of life of menopausal women. Design: A quasi-experimental research design (pretest /post-test control/study) was utilized. Settings: The study was conducted at obstetrics and gynecological outpatient clinic in Benha University hospital in Egypt. Sample: A purposive sample of 78 menopausal women among those attending previous mentioned setting. Tools: a structured interviewing questionnaire, health promotion lifestyle model Profile-II and menopause specific quality of life (MENQOL) tools were used. Results: Significant improvement in knowledge scores immediately after intervention (p < 0.0001) and three months follow-up (P < 0:001) in the study group. Highly statistically significant difference (p < 0:001) in mean health promoting behaviors score in the study group were found immediately after the intervention and three months follow-up compared to the control group. There was highly statistically significance difference between study and control group regarding all MENQOL after intervention and three months follow up. As all menopause specific quality of life scores decreased immediately post intervention and during follow-up in the study group MENQOL, scores increased in the control group with time. Conclusion: An educational intervention focused on health-promoting lifestyle modifications improves menopausal women's knowledge regarding menopause and menopause specific quality of life. Recommendations: Designing educational program to reduce the menopause-related health problems is a must.