Background: Transforming growth factor-beta1 (TGF-β1), a
member of transforming growth factor beta family, functions
as a multi-functional cytokine and plays a key role in cellular
growth, proliferation and differentiation. Aim of the work:
To evaluate the role of TGF-β1 polymorphisms 509 C>T and
TGF-β1 Gene expression in diagnosis of hepatocellular
carcinoma (HCC) in cirrhotic Egyptian patients due to
hepatitis C virus (HCV). Subjects and methods: Thirty five
cirrhotic with HCC patients, thirty cirrhotic without HCC
patients and 20 healthy volunteers were enrolled in this study.
TGF-β1 gene expression in peripheral blood was quantitated
using real-time polymerase chain reaction and molecular
study of TGF-β1 509 C>T (rs1800469) polymorphism by
Taqman allele discrimination was done for all subjects.
Results: Showed that TGF-β1 -509 CT genotype was the