Maha Zein El-Abedin Omar
Professor
Evaluation of Transforming Growth Factor- β 1 Gene Expression and Polymorphism in Diagnosis of Hepatocellular Carcinoma in HCV-Infected Patients
Benha Journal • 2020
Publication Information
Authors
Fatma M. Abdel Salam a, Maha Z. Omar a, Shuzan A. Mohammed b, Abeer M. El- Bahy a
Keywords
Not Available
Journal
Benha Journal
Publisher
Not Available
Volume
33
Issue
1
Pages
1-9
publication.type
Local
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Background: Transforming growth factor-beta1 (TGF-β1), a
member of transforming growth factor beta family, functions
as a multi-functional cytokine and plays a key role in cellular
growth, proliferation and differentiation. Aim of the work:
To evaluate the role of TGF-β1 polymorphisms 509 C>T and
TGF-β1 Gene expression in diagnosis of hepatocellular
carcinoma (HCC) in cirrhotic Egyptian patients due to
hepatitis C virus (HCV). Subjects and methods: Thirty five
cirrhotic with HCC patients, thirty cirrhotic without HCC
patients and 20 healthy volunteers were enrolled in this study.
TGF-β1 gene expression in peripheral blood was quantitated
using real-time polymerase chain reaction and molecular
study of TGF-β1 509 C>T (rs1800469) polymorphism by
Taqman allele discrimination was done for all subjects.
Results: Showed that TGF-β1 -509 CT genotype was the
member of transforming growth factor beta family, functions
as a multi-functional cytokine and plays a key role in cellular
growth, proliferation and differentiation. Aim of the work:
To evaluate the role of TGF-β1 polymorphisms 509 C>T and
TGF-β1 Gene expression in diagnosis of hepatocellular
carcinoma (HCC) in cirrhotic Egyptian patients due to
hepatitis C virus (HCV). Subjects and methods: Thirty five
cirrhotic with HCC patients, thirty cirrhotic without HCC
patients and 20 healthy volunteers were enrolled in this study.
TGF-β1 gene expression in peripheral blood was quantitated
using real-time polymerase chain reaction and molecular
study of TGF-β1 509 C>T (rs1800469) polymorphism by
Taqman allele discrimination was done for all subjects.
Results: Showed that TGF-β1 -509 CT genotype was the