Background: Epinephrine in liposuction solution mediated vasoconstriction thus decrease in
adrenergic side effects, local anesthetic toxicity, and bleeding. The optimum safe adrenaline
concentration was not well investigated.
Aim: This study aimed to compare between adrenaline 1 mg/L and 2 mg/L in tumescent fluid
concerning hemodynamics during abdominal liposuction operations.
Methods: Forty cases scheduled for liposuction for abdomen and flanks and body were
involved in this randomized, triple-blind, controlled trial. Cases were randomized equally into
two groups. Group A (low adrenaline concentration group): received 1 mg per liter of epinephrine.
Group B (high adrenaline concentration group): received 2 mg per liter of
epinephrine.
Results: Intraoperative heart rate and mean arterial blood pressure at base line were insignificantly
different between both groups (p value > 0.05) while at 30, 60, 90, and end of surgery
were significantly higher in group B group as opposed to group A (p value < 0.05). Incidence of
sinus tachycardia and PVCs were significantly higher in group B than group A (P < 0.05), while
surgeon satisfaction was comparable between both groups (p value > 0.05).
Conclusions: In liposuction procedures, the safest adrenaline concentration is 1 mg/L as
evidenced by hemodynamics stability and surgeon satisfaction thus even in high volume
liposuction, the adrenaline concentration should not exceed 1 mg/L and should be handled
to cover the used crystalloid solution