نهاد احمد فؤاد عبد الواحد
أستاذ
• Clinical significance of soluble programmed death-1(sPD-1) in rheumatoid arthritis patients: Relation to disease activity and functional status.
The Egyptian Rheumatologist • 2015
معلومات البحث
المؤلفون
Waleed A. Hassan, Eman A Baraka, Nehad A. Fouad
الكلمات المفتاحية
Not Available
المجلة العلمية
The Egyptian Rheumatologist
الناشر
Not Available
المجلد
25
العدد
Not Available
الصفحات
Not Available
publication.type
International
رابط البحث
Not Available
المواد المرفقة
Not Available
الملخص
Background: Programmed death-1 (PD-1) is an immuneregulatory molecule functioning by down-regulating immune responses. PD-1 is present on follicular helper T cells (TFH) and is important in the formation of plasma cells.PD-1 exists in a bioactive soluble form (sPD-1) and is thought to be implicated in disease activity in rheumatoid arthritis (RA).
Objectives: to measure the levels of soluble programmed death-1(sPD-1) in RA patients and to correlate it with clinical and laboratory parameters of disease activity and severity.
Method: We measured sPD-1 at in plasma (n = 60) and synovial fluid (SF) (n = 24) from patients with RA. We tested for correlations with the Disease Activity Score using 28 joint counts (DAS28), the Health Assessment Questionnaire(HAQ)score, immunoglobulin M rheumatoid factor (IgM-RF), anti-cyclic citrullinated peptide(anti-CCP) antibodies, C-reactive protein (CRP) and total Sharp score (TSS). We also measured sPD-1 in plasma from healthy volunteers (HV) (n = 30).
Results: In RA, sPD-1 concentrations in plasma (mean 1416.9 pg/ml) and SF (mean 1503.9 pg/ml) were increased compared with HV (median 165 pg/mL)(all p
Objectives: to measure the levels of soluble programmed death-1(sPD-1) in RA patients and to correlate it with clinical and laboratory parameters of disease activity and severity.
Method: We measured sPD-1 at in plasma (n = 60) and synovial fluid (SF) (n = 24) from patients with RA. We tested for correlations with the Disease Activity Score using 28 joint counts (DAS28), the Health Assessment Questionnaire(HAQ)score, immunoglobulin M rheumatoid factor (IgM-RF), anti-cyclic citrullinated peptide(anti-CCP) antibodies, C-reactive protein (CRP) and total Sharp score (TSS). We also measured sPD-1 in plasma from healthy volunteers (HV) (n = 30).
Results: In RA, sPD-1 concentrations in plasma (mean 1416.9 pg/ml) and SF (mean 1503.9 pg/ml) were increased compared with HV (median 165 pg/mL)(all p