Nehad Ahmed Foad
Professor
• Clinical significance of soluble programmed death-1(sPD-1) in rheumatoid arthritis patients: Relation to disease activity and functional status.
The Egyptian Rheumatologist • 2015
Publication Information
Authors
Waleed A. Hassan, Eman A Baraka, Nehad A. Fouad
Keywords
Not Available
Journal
The Egyptian Rheumatologist
Publisher
Not Available
Volume
25
Issue
Not Available
Pages
Not Available
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Background: Programmed death-1 (PD-1) is an immuneregulatory molecule functioning by down-regulating immune responses. PD-1 is present on follicular helper T cells (TFH) and is important in the formation of plasma cells.PD-1 exists in a bioactive soluble form (sPD-1) and is thought to be implicated in disease activity in rheumatoid arthritis (RA).
Objectives: to measure the levels of soluble programmed death-1(sPD-1) in RA patients and to correlate it with clinical and laboratory parameters of disease activity and severity.
Method: We measured sPD-1 at in plasma (n = 60) and synovial fluid (SF) (n = 24) from patients with RA. We tested for correlations with the Disease Activity Score using 28 joint counts (DAS28), the Health Assessment Questionnaire(HAQ)score, immunoglobulin M rheumatoid factor (IgM-RF), anti-cyclic citrullinated peptide(anti-CCP) antibodies, C-reactive protein (CRP) and total Sharp score (TSS). We also measured sPD-1 in plasma from healthy volunteers (HV) (n = 30).
Results: In RA, sPD-1 concentrations in plasma (mean 1416.9 pg/ml) and SF (mean 1503.9 pg/ml) were increased compared with HV (median 165 pg/mL)(all p
Objectives: to measure the levels of soluble programmed death-1(sPD-1) in RA patients and to correlate it with clinical and laboratory parameters of disease activity and severity.
Method: We measured sPD-1 at in plasma (n = 60) and synovial fluid (SF) (n = 24) from patients with RA. We tested for correlations with the Disease Activity Score using 28 joint counts (DAS28), the Health Assessment Questionnaire(HAQ)score, immunoglobulin M rheumatoid factor (IgM-RF), anti-cyclic citrullinated peptide(anti-CCP) antibodies, C-reactive protein (CRP) and total Sharp score (TSS). We also measured sPD-1 in plasma from healthy volunteers (HV) (n = 30).
Results: In RA, sPD-1 concentrations in plasma (mean 1416.9 pg/ml) and SF (mean 1503.9 pg/ml) were increased compared with HV (median 165 pg/mL)(all p