In recent years, the advancement in modern technologies in different fields has resulted to have huge data sets on the web. It gives rise to concerns about the security and protection of big data. The advent of blockchain technology has caused a revolution in the security field for different applications. Each node involved in the blockchain contains the distributed ledger which enhances security and data transparency. Illegal users cannot perform any fault transaction in the blockchain network. In this paper, we highlight how blockchain is used to protect big data. We explain the problems that the blockchain faced with big data and its solutions. We summarize recent works of blockchain with big data and the present issues and trends. We prove that blockchain technology is still in the early stages of verification and that there are currently no large-scale application scenarios, particularly in the big data industry. Finally, we narrow our study to the healthcare industry and offer the following research directions for its primary issues.