The present study aims to investigate the effect of cabbage and radish leaves on obesity biological changes induced in rats. Thirty male albino rats (140±9.56 per each), were divided into two main groups, the first group (Group 1, 5 rats) still fed on basal diet and the other main group (40 rats) classified into seven sub groups as follow: group (2), fed on DIO as a positive control; groups (3-8), fed on DIO containing cabbage leaves powder (CLP) and radish leaves powder (RLP) by the ratio of 2.5, 5.0 and 7.5%, respectively. Feeding of rats on diet induced obesity (DIO) leads to increase the BW than the control group. At the end of the experiment (8 weeks), rats of the normal group recorded 180.11 % of baseline for the BW while obese group was 228.43% of baseline. Replacement of wheat flour with CLP and RLP induced significant (p≤0.05) de-creasing on BW of the obese rats which recorded 203.03, 190.78 and 188.79% (CLP) and 217.04, 214.00 and 209.56% of baseline for the ratio of 2.5, 5.0 and 7.5%, respectively. Biochemical analy-sis data indicated that obesity induced a significant increase in se-rum glucose, serum lipid profile (TG, TC, LDL and VLDL) and serum acetylcholine esterase compared to normal controls. Feeding on 2.5, 5.0 and 7.5%, of CLP and RLP exhibited a significant im-provement (p≤0.05) in all of these parameters by different rates. The amelioration effects were higher in CLP than RLP. In conclu- sion, these results provide a basis for the use of the tested plant parts (CLP and RLP) in an important therapeutic feeding applica-tion which is the prevention and early treatment of obesity.