Background: Cystic fibrosis (CF) is a genetic disorder caused by mutations in the CFTR ion
channel leading to abnormal secretions in multiple body systems and eventually respiratory failure.
This study aimed to evaluate the compliance of educational protocol with parents’ adherence to
caring for their children with cystic fibrosis. A quasi-experimental design was utilized to conduct
study. All available (40) parents accompanying their children with cystic fibrosis and attending the
genetics outpatient and pediatric intensive care unit at El-Demerdash Hospital, affiliated with Ain
Shams University Hospitals during study period (6 months). Five tools were used, namely Tool I:
Personal and medical data sheet, Tool II: Self-reported practice questionnaire, Tool III: Care
adherence scale, Tool IV: Barriers to treatment adherence scale and Tool V: Cystic Fibrosis Self
Efficacy-Questionnaire. Study results shows that; less than three-quarters of the studied parents had
poor levels of adherence to educational protocol, which improved to most of them had good levels
of adherence at post and follow-up compliance educational protocol implementation. Study
concluded that implementation of compliance educational protocol improved parents’ adherence to
caring for their children with cystic fibrosis. Study recommended similar studies on larger samples
and regions to generalize the results.