Background: Ovarian cancer is a lethal gynecological malignancy worldwide. The immune system plays a key role in preventing tumor development. Angiogenesis and immune evasion are vital for ovarian cancer progression and metastasis. Aim: This work aimed to evaluate the expression of PD-L1, VEGF and CD8 +T cells in ovarian serous carcinomas and correlate them with clinic-pathological variables. Material and methods: An Immunohistochemical study of PD-L1, VEGF and CD8+ T cells was performed on 50 cases of ovarian serous carcinomas. Results: PD-L1 & VEGF were over-expressed with statistical significance , in higher grade (P