Youssef Mohamed yassein elgazar
Lecturer
Assessment of Doppler Ultrasonography and Hepatocyte MiRNA-122 for the Diagnosis of Acetaminophen-induced Acute Hepatic Injury in Dogs
Egyptian Journal of Veterinary Sciences • 2024
Publication Information
Authors
Youssef M. Y. Elgazzar*1, Mohamed M. Ghanem1, Yassein M. Abdel-Raof1, Heba M.
EL-khaiat1, Mahmoud A. Y. Helal1
Keywords
Acetaminophen, Dogs, Doppler ultrasonography, MiRNA-122, Ultrasound
Journal
Egyptian Journal of Veterinary Sciences
Publisher
Not Available
Volume
56
Issue
12
Pages
Not Available
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
HIS study aimed to evaluate the diagnostic value of Doppler ultrasound parameters of the
hepatic artery, portal vein, and interlobar artery as well as the potential use of miRNA-122 for
the diagnosis of acetaminophen-induced acute hepatic injury in dogs. Ten healthy mongrel
dogs were orally administered 200 mg/kg body weight of acetaminophen daily for ten days. Clinical,
Biochemical, Ultrasonographic, and Doppler ultrasonographic examinations were performed for all
dogs on zero day before induction, 3rd day, and the 10th day of induction. The results of the current
study showed that depression, dullness, and jaundice signs appeared in dogs on the 10th day of
induction. Significant increase (P
hepatic artery, portal vein, and interlobar artery as well as the potential use of miRNA-122 for
the diagnosis of acetaminophen-induced acute hepatic injury in dogs. Ten healthy mongrel
dogs were orally administered 200 mg/kg body weight of acetaminophen daily for ten days. Clinical,
Biochemical, Ultrasonographic, and Doppler ultrasonographic examinations were performed for all
dogs on zero day before induction, 3rd day, and the 10th day of induction. The results of the current
study showed that depression, dullness, and jaundice signs appeared in dogs on the 10th day of
induction. Significant increase (P