Amira Elsayed Abd Elkhalek Soliman Eid
Asst. Professor
Expression analysis and potential validity of PRMT3, IGF2BP1 in adrenocortical carcinoma and their correlation with FOXM1
Egyptian Journal of Pathology • 2025
Publication Information
Authors
Marwa S.A. Allaha
, Mona Ahmeda
, Heba Abd El Kariemb,c
, Amira ElSayed
Keywords
adrenocortical carcinoma, FOXM1, IGF2BP1, PRMT3
Journal
Egyptian Journal of Pathology
Publisher
Wolters Kluwer - Medknow
Volume
44
Issue
2
Pages
125-136
publication.type
Local
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
Background
PRMT3 and IGF2BP1 overexpression has been detected in several malignancies
and has been recognized by their oncogenic role. No studies have handled the
expression of PRMT3 and IGF2BP1 in adrenocortical carcinoma (ACC) and
their association with outcome. This work aimed at exploring the significance
of PRMT3 and IGF2BP1 expression in ACC and their correlation with FOXM1
expression.
Patients and methods
Immunohistochemistry accessed quantitative expression of PRMT3, IGF2BP1,
and FOXM1 proteins in 60 cases of ACC and 20 cases of adrenocortical adenoma.
IGF2BP1 mRNA and PRMT3 mRNA were also evaluated using a quantitative realtime PCR.
Results
PRMT3, IGF2BP1, and FOXM1 expression were statistically highly significant in
ACC compared to adrenocortical adenoma (P
PRMT3 and IGF2BP1 overexpression has been detected in several malignancies
and has been recognized by their oncogenic role. No studies have handled the
expression of PRMT3 and IGF2BP1 in adrenocortical carcinoma (ACC) and
their association with outcome. This work aimed at exploring the significance
of PRMT3 and IGF2BP1 expression in ACC and their correlation with FOXM1
expression.
Patients and methods
Immunohistochemistry accessed quantitative expression of PRMT3, IGF2BP1,
and FOXM1 proteins in 60 cases of ACC and 20 cases of adrenocortical adenoma.
IGF2BP1 mRNA and PRMT3 mRNA were also evaluated using a quantitative realtime PCR.
Results
PRMT3, IGF2BP1, and FOXM1 expression were statistically highly significant in
ACC compared to adrenocortical adenoma (P