Rasha Mahmoud Abdrabh Mahmoud
Asst. Professor
Significance of CXCL9 and Vascular Endothelial Growth Factor-Α (VEGF-Α) Expression in Colorectal Adenocarcinoma :(Immunohistochemical Study)
• 2022
Publication Information
Authors
Samah I. Saleh, Taghreed Abd EL Samea, Eman S. Omar, Rasha Mahmoud
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publication.type
Local
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Abstract
Background: Colorectal carcinoma (CRC) is the third most common
cancer in the world. The chemokine CXCL9 is a small molecule
belongs to (CXC family) which secreted by (IFN-γ) stimulated
macrophages. VEGF-α plays central role in the regulation of
angiogenesis and lymphangiogenesis. Aim : This work aimed to
evaluate the role of CXCL9 and VEGF α in colorectal
adenocarcinoma. Material and method: This retrospective study was
carried upon 50 cases of colorectal adenocarcinoma. CXCL9 and
VEGFα immunostaining was done and assessed for each case. Results:
There was an insignificant statistical correlation between both CXCL9
and VEGF -α expression and patient`s age, sex, tumor size and site (P
value >0.05). But there was a highly significant inverse statistical
correlation between CXCL9 expression and tumor grade, depth of
tumor invasion, lymph node metastasis, distant metastasis
lymphovascular invasion and tumor stage (P value
cancer in the world. The chemokine CXCL9 is a small molecule
belongs to (CXC family) which secreted by (IFN-γ) stimulated
macrophages. VEGF-α plays central role in the regulation of
angiogenesis and lymphangiogenesis. Aim : This work aimed to
evaluate the role of CXCL9 and VEGF α in colorectal
adenocarcinoma. Material and method: This retrospective study was
carried upon 50 cases of colorectal adenocarcinoma. CXCL9 and
VEGFα immunostaining was done and assessed for each case. Results:
There was an insignificant statistical correlation between both CXCL9
and VEGF -α expression and patient`s age, sex, tumor size and site (P
value >0.05). But there was a highly significant inverse statistical
correlation between CXCL9 expression and tumor grade, depth of
tumor invasion, lymph node metastasis, distant metastasis
lymphovascular invasion and tumor stage (P value