Reda ibrahim ahmed El kammar
Asst. Professor
Testicular toxicity of cisplatin in rats: ameliorative effect of lycopene and N-acetylcysteine.
Environmental Science and Pollution Research • 2022
Publication Information
Authors
Asmaa Elsayed; Ashraf Elkomy; Mohamed Alkafafy; Reda Elkammar; Anwar El‑Shafey; Ahmed Soliman; Mohamed Aboubakr.
Keywords
Cisplatin · N-acetylcysteine · Lycopene · Oxidative stress · Testosterone · Testes
Journal
Environmental Science and Pollution Research
Publisher
Not Available
Volume
29
Issue
Not Available
Pages
24077–24084
publication.type
International
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
Lycopene (LP) and N-acetylcysteine (NAC) protective effects were assessed for testicular toxicity mediated by cisplatin
(CP) in rats. Forty-nine rats were divided into 7 groups (n = 7); these groups included the control group (saline, PO), LP (10
mg/kg, PO), NAC (150 mg/kg, PO), CP (7.5 mg/kg, IP) on the 27th day of the study, LP + CP, NAC+CP, and LP + NAC +
CP. Serum levels of testosterone were decreased following CP injection. Malondialdehyde (MDA) has been increased with
considerable glutathione (GSH), and dismutase superoxide (SOD) and catalase (CAT) decline in the testis tissues after CP
injection. CP caused severe alterations in testicular tissues and elevated caspase-3 expression. Besides that, LP and/or NAC
administration improved CP-induced testicular toxicity and apoptosis, probably via their antioxidant properties.
(CP) in rats. Forty-nine rats were divided into 7 groups (n = 7); these groups included the control group (saline, PO), LP (10
mg/kg, PO), NAC (150 mg/kg, PO), CP (7.5 mg/kg, IP) on the 27th day of the study, LP + CP, NAC+CP, and LP + NAC +
CP. Serum levels of testosterone were decreased following CP injection. Malondialdehyde (MDA) has been increased with
considerable glutathione (GSH), and dismutase superoxide (SOD) and catalase (CAT) decline in the testis tissues after CP
injection. CP caused severe alterations in testicular tissues and elevated caspase-3 expression. Besides that, LP and/or NAC
administration improved CP-induced testicular toxicity and apoptosis, probably via their antioxidant properties.