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The protective effects of geraniin against initial and intermediate carbonyl-induced glycoxidation stress in bovine serum albumin models
• 2025
Publication Information
Authors
Remah Sobhy, Jianing Zhang, Zhihua Li, Yangyang Jia, Ali Korin, Mahmoud Salah, Mohamed Abdin, Zou Xiaobou
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publication.type
International
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Supplementary Materials
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Abstract
This study elucidates the multi-target anti-glycoxidation mechanisms of geraniin (G), a hydrolysable tannin, using bovine serum albumin (BSA) models incubated with glucose (BSA-G), glyoxal (BSA-GO), and methylglyoxal (BSA-MGO). Through comprehensive analysis employing multispectral analysis, molecular docking, and confocal microscopy, G demonstrated significant inhibitory capacity against advanced glycoxidation end-product (AGEs) formation across three stages. In the early stage, G competitively binds to specific lysine (Lys127–434) and arginine residues (Arg185–456) in BSA-subdomains, effectively reducing glucose-BSA covalent binding by 63 % (at 90 μM G; p